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b, Effect of retinoic acid on growth and survival of human neuronal progenitors (hNPCs). (A) Human adult neurons (hNPCs) were transduced with an adenoviral gene encoding a TRAIL-GFP reporter construct. hNPCs were treated with either increasing concentrations of Retinoic Acid (RA) or a non-specific retinoic acid receptor (RAR) antagonist (AGN193109) in the absence or presence of TRAIL. Cell growth was measured over a 72 h time course and plotted as relative cell numbers. Data are mean ± s.e.m. of three biological replicates. Two-way ANOVA analysis indicated that there was a significant effect of retinoic acid treatment (p = 827ec27edc